Monday, January 31, 2011

The Brainwave

The β-brainwave (13~38 Hz) dominates our consciousness when awake. θ-brainwave (4~7 Hz) reflects our subconsciousness & dreaming. δ-brainwave (0.5~3 Hz) reflects our unconsciousness. The α-brainwave (8~12 Hz) plays a role of bridging our sub- & consciousness to develop our Extra Sensory Perception & Psychokinesis. The α-brainwave will be largely decreased when we are eye-opened and getting older. Meditation can help us to convert our β-brainwave to α-brainwave.
Simply saying, slow down the biorhythms of your brain.

GFAJ-1 Strain

The most recent and biggest news to the academic community has came from NASA these days. They just announced the evidences of new life form and claimed the GFAJ-1 strain can live under the environment without Phosphorus but using Arsenic instead. To me they still haven't shown the direct evidence that Arsenic directly replaced the P in phosphodiester bond of DNA backbone, ATP and other molecules.
Not only for lacking of direct evidence (eventhough the isotope labelling showed the radioactivity came with nucleic acid fraction together, it could still be interpreted as a contamination), it is also still arguable about the stability of As-O bond. From chemical viewpoint, the As-O bond is very unstable and much weaker than P-O bond. Really don't know how does this tiny creature work with Arsenic.

The strongest superacid in the Earth

Fluoroantimonic acid (the mixture of HF and SbF5) is the strongest known superacid (much stronger than Aqua Regia), which can almost protonate all known organic compounds. If mixing it with water then it will cause explosion immediately.

Movies "Wall Street I & II"

Alex: Just finished watching two movies, the "Wall Street I" and "Wall Street II (Money Never Sleeps)". Ironically the actor's lines of "Wall Street I" is even still very true today especially in the aftermath of "Financial Tsunami". Those who invented and designed varied financial products and derivatives are all graduated from excellent schools such as the department of mathematics of MIT etc. Wrongly using their intelligence and gradually become extremely selfish and greedy opportunists after soaked into the dye-vat of wall street. I oppose Communism but I do prefer the role that Martin Sheen played in "Wall Street I" and the words he said in the end.
Alex: Gordon Gekko said "Greedy is good". Moral Hazard is turning the nation into evil empire.

Mario: Greed is never satisfied, and that is why... greed is bad!

Sunday, January 9, 2011

New method in developing biomarkers for early diagnosis of diseases

Combinatory Chemistry is becoming a powerful tool in developing new theraputic & diagnostic agents. Similar to the inhibitory RNA aptamer against botulinum neurotoxin that I screened, the "peptoids library (artificially synthetic molecules)" has been recently screened to identify the potential candidates that stimulate more IgG binding in patietns than that in healthy person. Simply saying, you can inject the same peptoid into a "normal:diseased" pair of animals/human. If the immune system of the tested animals/human triggered an equal amount of IgG against the injected peptoid in both healthy and diseased group then this peptoid is useless. Therefore you can discard it and try the next peptoid candidate. You just keep repeating this process till you can find a peptoid candidate that trigger the immune system of diseased animal/human to produce at least three-fold higher levels of IgG than that in healthy animal/human. Thus this peptoid candidate becomes an useful biomarker to be used in early diagnosis of disease onset in other potential patients. Under this concept the identification of antigens of diseases become non-revelant. You don't even need to know the antigens of the immune response first. This new method can be applied in the early diagnosis of many neuro-degenerative diseases such as Alzheimer disease and Parkinson disease and so on.